Arkivoc

Synthesis and bioactivity of some 2-oxo-5-aryl-3-hydrazone and 2-oxo-5-aryl-4-hydrazone pyrrolidine derivatives

…, N Najim, NS Mansor, S Sarman, Z Shaameri, MM Zain…

Index: Mohammat, Mohd Fazli; Najim, Nigar; Mansor, Nurul Shulehaf; Sarman, Sharil; Shaameri, Zurina; Zain, Mazatulikhma Mat; Hamzah, Ahmad Sazali Arkivoc, 2011 , vol. 2011, # 9 p. 429 - 438

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Citation Number: 3

Abstract

Abstract 2-Aryl-4, 5-dioxopyrrolidine-3-carboxylate and 5-aryl-2, 4-dioxopyrrolidine-3- carboxylate derivatives were successfully synthesized via carbonyl-based multiple component reaction and Dieckmann cyclization, respectively. Successive functional group transformations which include decarboxylation and hydrazonation afforded 2-oxo-5-aryl-3- hydrazone and 2-oxo-5-aryl-4-hydrazone derivatives. Compound 3d exhibited activity ...