Asymmetric transformations of 1, 1-disubstituted alkenes provide important building blocks for chemical synthesis, but are often plagued with low stereoselectivities because it can be difficult for a chiral reagent or catalyst to discriminate between the enantiotopic faces of these substrates.[1] Among the available methods, asymmetric dihydroxylation (AD) stands out as one of the more successful, and can provide high enantioselectivities in certain ...
