The Journal of Organic Chemistry

Nickel-catalyzed Markovnikov addition of hydrogen cyanide to olefins. Application to nonsteroidal antiinflammatories

WA Nugent, RJ McKinney

Index: Nugent, William A.; McKinney, Ronald J. Journal of Organic Chemistry, 1985 , vol. 50, # 25 p. 5370 - 5372

Full Text: HTML

Citation Number: 46

Abstract

sulfur dioxide (ca. 5 mL) was added to a freshly prepared solution (THF, 80 mL) of ketene imine 3a (0.59 g, 3.17 mmol) at-40" C. After warmup at room temperature and evaporation of the excess of sulfur dioxide, the residue was chromatographed@ ioz, ethyl ether), yielding 0.50 g (1.106 mmol, 70%) of bis [(N-mesitylcarbamoyl) cyclopropyl] sulfoxide (8): mp 225- 226" C (from methanol); IR (CC14, C2C14, CSz) 3200-3100 (NH), 1670-1640 (CONH), ...