Alkylsulfanyl-1, 2, 4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure–activity relationships

P Polucci, P Magnaghi, M Angiolini, D Asa…

Index: Journal of Medicinal Chemistry, , vol. 56, # 2 p. 437 - 450

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Citation Number: 34

Abstract

... Journal of Medicinal Chemistry. ... Nerviano Medical Sciences Srl ... This, together with the difficulty encountered in attempts to obtain cocrystals suitable for X-ray diffraction, led us to undertake medicinal chemistry optimization through a traditional iterative SAR approach. ...