Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1′, 2′-bis (hydroxymethyl) cycloprop-1′-yl] methyl} guanine analogues

T Ostrowski, B Golankiewicz, E De Clercq…

Index: Ostrowski, Tomasz; Golankiewicz, Bozenna; De Clercq, Erik; Andrei, Graciela; Snoeck, Robert European Journal of Medicinal Chemistry, 2009 , vol. 44, # 8 p. 3313 - 3317

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Citation Number: 11

Abstract

A series of tricyclic analogues of acyclovir and 9-{[cis-1′, 2′-bis (hydroxymethyl) cycloprop- 1′-yl] methyl} guanine substituted in the 6 position with thien-2-yl, 5-bromothien-2-yl or furan-2-yl group were synthesized. The new compounds 5a–f were evaluated for their activity in vitro against varicella-zoster virus (VZV) and cytomegalovirus (CMV). The marked anti-VZV activities of 5a–f remained comparable to those of their previously described 6- ...