Synthesis and Physicochemical Properties of Alternating. alpha.,. beta.-Oligodeoxyribonucleotides with Alternating (3'. fwdarw. 3')-and (5'. fwdarw. 5')-Internucleotidic …

M Koga, A Wilk, MF Moore, CL Scremin…

Index: Koga; Wilk; Moore; Scremin; Zhou; Beaucage Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1520 - 1530

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Citation Number: 35

Abstract

A simple and straightforward synthesis of a-2'-deoxycytidine and a-2'-deoxyadenosine derivatives 6a, b has been achieved from commercial N4-benzoyl-@-2'-deoxycytidine and N6-benzoyl-@-2 '-deoxyadenosine, respectively. Properly protected a-2 '- deoxyribonucleosides 8a-d were converted to the corresponding 5'-phosphoramidite derivatives 9a-d. These and commercial@-2'-deoxyribonucleoside 3'-phosphoramidites ...