1, 2??Didehydro??3??and??4??(trifluoromethoxy) benzene: The “Aryne” Route to 1??and 2??(Trifluoromethoxy) naphthalenes

M Schlosser, E Castagnetti

Index: Schlosser, Manfred; Castagnetti European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997

Full Text: HTML

Citation Number: 10

Abstract

Abstract Upon treatment of 1-bromo-2-(trifluoromethoxy) benzene with lithium diisopropylamide (LIDA) at− 100 C, 3-bromo-2-(trifluoromethoxy) phenyllithium is generated. It can be trapped as such, but isomerizes to afford 2-bromo-6-(trifluoromethoxy) phenyllithium when the temperature is raised to− 75 C. The latter intermediate can be directly obtained from 1-bromo-3-(trifluoromethoxy) benzene. 1-Bromo-4-(trifluoromethoxy ...