Tetrahedron letters

Synthesis of monofluorinated 1-(naphthalen-1-yl) piperazines

…, DA Favor, MA Stier, J Yip, T Rankin, Q Ding, SN Maiti

Index: Repine, Joseph T.; Johnson, Douglas S.; White, Andrew D.; Favor, David A.; Stier, Michael A.; Yip, Judy; Rankin, Trent; Ding, Qizhu; Maiti, Samarendra N. Tetrahedron Letters, 2007 , vol. 48, # 31 p. 5539 - 5541

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Citation Number: 10

Abstract

... Scheme 6. Reagents and conditions: (a) H 2 SO 4 , NaN 3 , CHCl 3 , 40 °C, 96%; (b) 48% HBF 4 , NaNO 2 , THF; NaBF 4 , 69%; (c) Pd(OAc) 2 , NaO t Bu, 2-(dicyclohexylphosphino)biphenyl, Boc-piperazine, toluene, 80 °C, 38%; (d) TFA, CH 2 Cl 2 , 0 °C, 89%. ... 6; (b)Johnson, D. S; Repine, JT; White, AD US 7,160,888, 2007. 7; (a)Frost, J.; Gaudilliere, B.; Rousseau, J.; Dupont, R.; Manoury, P.; Obitz, D.; Eur. Pat. Appl. EP 343050, 1989. ...