Manganese??Promoted Regioselective Ring??Opening of 2, 3??Epoxy Acid Derivatives: A New Route to α??Hydroxy Acid Derivatives

…, PL Bernad, H Rodríguez??Solla, P Diaz

Index: Concellon, Jose M.; Bernad, Pablo L.; Rodriguez-Solla, Humberto; Diaz, Pamela Advanced Synthesis and Catalysis, 2009 , vol. 351, # 13 p. 2178 - 2184

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Citation Number: 4

Abstract

Abstract A simple and general methodology directed towards the synthesis 3-aryl-2-hydroxy amides, or esters with total regioselectivity from the easily available 2, 3-epoxy amides or esters, promoted by active manganese is described. Utilizing enantiopure epoxy amides as starting materials, the corresponding 3-aryl-2-hydroxy amides in enantiopure form are also available. Some synthetic applications of selected examples of 3-aryl-2-hydroxy ...