Pyrrolo [2, 3-b] quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay

A Nakhi, MS Rahman, R Kishore, CLT Meda…

Index: Nakhi, Ali; Rahman, Md. Shafiqur; Kishore, Ravada; Meda, Chandana Lakshmi T.; Deora, Girdhar Singh; Parsa, Kishore V.L.; Pal, Manojit Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 20 p. 6433 - 6441

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Citation Number: 12

Abstract

2-Substituted pyrrolo [2, 3-b] quinoxalines having free NH were prepared directly from 3- alkynyl-2-chloroquinoxalines in a single pot by using readily available and inexpensive methane sulfonamide (or p-toluene sulfonamide) as an ammonia surrogate. The reaction proceeded in the presence of Cu (OAc) 2 affording the desired product in moderate yield. The crystal structure analysis of a representative compound and its supramolecular ...