Preparation of 5-(2-Methoxy-4-nitrophenyl) oxazole: A Key Intermediate for the Construction of VX-497

RJ Herr, DJ Fairfax, H Meckler…

Index: Organic Process Research and Development, , vol. 6, # 5 p. 677 - 681

Full Text: HTML

Citation Number: 18

Abstract

... from the acidic aqueous layer were examined (eg, extraction with other organic solvents, and ... After chromatographic purification, this procedure afforded the desired aryl aldehyde 8 as an orange ... Thus, this two-step process to provide 8 was achieved from commercially available ...