Bioactive conformation of 1-arylpiperazines at central serotonin receptors

…, JP Springer, GE Martin, M Williams

Index: Huff, Joel R.; King, Stella W.; Saari, Walfred S.; Springer, J. P.; Martin, Gregory E.; Williams, Michael Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 945 - 948

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Citation Number: 29

Abstract

A number of 1-arylpiperazines have been characterized as dired-acting serotonin agonists. Conformational parameters of this class that may affect receptor recognition and binding have been examined through the analysis of X-ray data and synthesis of rigid analogues. Radioligand binding studies indicate that 2, 3, 4, 4a, 5, 6-hexahydro-g-(tri-fluoromethyl)-M- pyrazino [l, Za] quinoline (13), an arylpiperazine that mimics the X-ray conformation of the ...