TBD??Catalyzed Direct 5??and 6??enolexo Aldolization of Ketoaldehydes

C Ghobril, C Sabot, C Mioskowski…

Index: Ghobril, Cynthia; Sabot, Cyrille; Mioskowski, Charles; Baati, Rachid European Journal of Organic Chemistry, 2008 , # 24 p. 4104 - 4108

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Citation Number: 26

Abstract

Abstract Treatment of unfunctionalized acyclic ketoaldehydes with a catalytic amount of 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene induces a direct intramolecular 5-and 6-enolexo aldolization, furnishing 2-ketocyclopentanols and 2-ketocyclohexanols in good-to-excellent yields.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)