Synthesis of the lnterferon-. ALPHA. Inducer lmiquimod by Thermal Electrocyclic Reactions of 1-and 2-Azahexatriene Systems.

H YOSHIOKA, Y MATSUYA, T CHOSHI…

Index: Yoshioka, Haruyuki; Matsuya, Yuhji; Choshi, Tominari; Sugino, Eiichi; Hibino, Satoshi Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 709 - 714

Full Text: HTML

Citation Number: 25

Abstract

712 J=2Hz, imidazole C4 or C5~H). MS m/z: 170 (M1). HRMS Calcd for CS}IISNZS: 170.0877. Found: 170.0865. S-Bromo-1-isohutyl-2-methylthioimidazole (8) NBS (1.15 g, 6.46 mmol) was added to a solution of7 (1.0 g, 5.87mmol) in CCl4 (301111) and the mixture was stirred for 1 h at room temperature. The mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography (silica gel, 20 g) with EtOAc—hexane (1 z 19, ...