Applications of optically active aryl cyanohydrins in the synthesis of α-hydroxy aldehydes, α-hydroxy ketones and β-hydroxy amines

…, GS Jayatilake, BR Matthews, KG Watson

Index: Jackson, W. Roy; Jacobs, Howard A.; Jayatilake, Gamini S.; Matthews, Barry R.; Watson, Keith G. Australian Journal of Chemistry, 1990 , vol. 43, # 12 p. 2045 - 2062

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Citation Number: 95

Abstract

Abstract Cyanohydrins, prepared in high optical purity from aryl aldehydes, have been converted into α-hydroxy aldehydes, β-hydroxy ketones and β-hydroxy amines without any racemization and frequently with good stereoselectivity for the erythro-diastereoisomer (> 90%) at the newly introduced stereogenic centre.