An NMR study of dinucleoside monophosphates with an O4-ethylated thymine. d (e4TpT) and d (Tpe4T)

GW Buchko, FE Hruska…

Index: Buchko; Hruska; Sadana Canadian Journal of Chemistry, 1989 , vol. 67, # 1 p. 109 - 119

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Citation Number: 8

Abstract

Syntheses are described for d (e4pT)(1) and d (Tpe4)(2), the O4-ethylated analogues of d (TpT)(3), and mass spectrometric (FAB), 1H nuclear magnetic resonance (300 MHz), and circular dichroic data are provided for the three molecules. The [MH]-ions as well as the

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tert-Butyldimethylsilyl chloride Structure

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tert-Butyldimet...

Thymidine Structure

50-89-5

Thymidine

~65%

5'-O-TBDMS-thymidine Structure

40733-28-6

5'-O-TBDMS-thymidine

1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione Structure

40733-26-4

1-((2R,4S,5R)-4...

tert-Butyldimethylsilyl chloride Structure

18162-48-6

tert-Butyldimet...

Thymidine Structure

50-89-5

Thymidine

~0%

5'-O-TBDMS-thymidine Structure

40733-28-6

5'-O-TBDMS-thymidine

1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione Structure

40733-26-4

1-((2R,4S,5R)-4...


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