Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes

M Foroozesh, G Primrose, Z Guo, LC Bell…

Index: Foroozesh, Maryam; Primrose, Ginny; Guo, Zuyu; Bell, L. Chastine; Alworth, William L.; Guengerich, F. Peter Chemical Research in Toxicology, 1997 , vol. 10, # 1 p. 91 - 102

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Citation Number: 83

Abstract

Aryl acetylenes have been investigated as inhibitors of cytochrome P450 (P450)-dependent alkoxyresorufin dealkylation activities in liver microsomes prepared from rats exposed to β- naphthoflavone, isosafrole, or phenobarbital. Many of the acetylenes investigated produce ...

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1-PYREN-4-YL-ET...

~62%

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185506-23-4

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trimethyl(2-pyren-1-ylethynyl)silane Structure

185506-32-5

trimethyl(2-pyr...

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10549-27-6

2-bromo-4,5,9,1...

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trimethyl(2-pyren-1-ylethynyl)silane Structure

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92-91-1

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61948-01-4

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