A novel histamine 2 (H2) receptor antagonist with gastroprotective activity. II. Synthesis and pharmacological evaluation of 2-furfuryl-thio and 2-furfurylsulfinyl …

N Hirakawa, H Matsumoto, A Hosoda…

Index: Hirakawa, Nobuhiko; Matsumoto, Hajime; Hosoda, Akihiko; Sekine, Akihiro; Yamaura, Tetsuaki; Sekine, Yasuo Chemical and Pharmaceutical Bulletin, 1998 ,  vol. 46,  # 4  p. 616 - 622

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Citation Number: 16

Abstract

We recently found that N-[3-[3-(piperidinomethyl) phenoxy] propyl] acetamide derivatives with a thioether function showed gastric anti-secretory and gastroprotective activities and that the thioether function (particularly furfurylthio or furfurylsulfinyl) was essential for gastroprotection. In the present study, a series of 2-furfurylthio and 2-furfurylsulfinyl acetamide derivatives were synthesized and evaluated for histamine H 2 receptor ...