e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Helvetica chimica acta
Enantioselective Syntheses of α??Amino Acids from 10??(Aminosulfonyl)??2??bornyl Esters and Di (tert??butyl) Azodicarboxylate. Preliminary Communication
W Oppolzer, R Moretti
Index: Oppolzer, Wolfgang; Moretti, Robert Helvetica Chimica Acta, 1986 , vol. 69, p. 1923 - 1926
Abstract Succesive treatment of chiral esters 1 with LiN (i-Pr) 2/Me 3 SiCl and di (tert-butyl) azodicarboxylate/TiCl 4/Ti (i-PrO) 4 gave N, N′-di [(tert-butoxy) carbonyl] hydrazino esters 9 which on deacylation, hydrogenolysis, transesterification, and acidic hydrolysis furnished (2S)-α-amino acids 6 in high enantiomeric purity with efficient recovery of the auxiliary alcohol 7.
![[(1S,2R)-10-(dicyclohexylaminosulfonyl)born-2-yl] 3-phenylpropionate Structure](https://image.chemsrc.com/caspic/300/110508-12-8.png)
![[(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl] (2S)-2-amino-3-cyclohexylpropionate Structure](https://image.chemsrc.com/caspic/458/110449-53-1.png)
![[(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl] isovalerate Structure](https://image.chemsrc.com/caspic/258/110449-36-0.png)
![[(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl] (2R)-2-aminoisovalerate Structure](https://image.chemsrc.com/caspic/437/110449-49-5.png)
![[(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl] [(2S)-2-(N,N'-di-tert-butoxycarbonyl)]hydrazino-3-phenylpropionate Structure](https://image.chemsrc.com/caspic/127/110449-44-0.png)