Synthesis and in vitro antiproliferative activity of diphenyl (sulphonylpiperidin-4-yl) methanol derivatives

SBB Prasad, K Vinaya, CSA Kumar, S Swarup…

Index: Benaka Prasad; Vinaya; Ananda Kumar; Swarup, Sanjay; Rangappa Medicinal Chemistry Research, 2010 ,  vol. 19,  # 3  p. 220 - 235

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Citation Number: 5

Abstract

Abstract A series of novel diphenyl (piperidin-4-yl) methanol derivatives 10 (a–n) were synthesized and characterized by 1 H NMR, LC/MS, FTIR, and elemental analyses. All the synthesized compounds were evaluated for cell proliferation by MTT assay. The antiproliferative effects of the synthesized compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines, namely HeLa cells, HT-29 cells, MCF-7 ...