Synthesis and in vitro activity of various derivatives of a novel thromboxane receptor antagonist,(.+-.)-(5Z)-7-[3-endo [(phenylsulfonyl) amino] bicyclo [2.2. 1] hept-2-exo …

…, M Ohtani, F Watanabe, K Uchida, H Arita…

Index: Narisada, Masayuki; Ohtani, Mitsuaki; Watanabe, Fumihiko; Uchida, Kiyohisa; Arita, Hitoshi; et al. Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 9  p. 1847 - 1854

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Citation Number: 115

Abstract

Chemical studies in our laboratories have been focused on the design and synthesis of novel sulfonyl derivatives 13a-t of (&)(52)-(3-enclo-aminobicyclo [2.2. 11 hept-2-exoy1) heptenoic acid (VI), the structure of which was chosen as a rigid ring analogue of 13- azaprostanoic acid (13-A. PA, VII)," a TxA2 antagonist. The phenylsulfonyl derivative 13a of VI, designed on the basis of the latent similarity to the non-prostanoid antagonist BM- ...