Abstract 5-(3, 4-Dimethoxyphenyl) pyrazine-2, 3-dicarbonitrile reacts with methanol to give addition products, 3-methoxyiminopyrazine-2-carbonitrile and 2-methoxyiminopyrazine-3- carbonitrile derivatives, and/or substitution products, 3-methoxypyrazine-2-carbonitrile and 2- methoxypyrazine-3-carbonitrile derivatives. The selectivity between the addition and substitution depends on solvent polarity, base, and reaction time. The experimental results ...
