e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
… of (1'R, 3R, 4R)-4-acetoxy-3-[1'-((tert-butyldimethylsilyl) oxy) ethyl]-2-azetidinone and other 3-(1'-hydroxyethyl)-2-azetidinones from (S)-(+)-ethyl 3-hydroxybutanoate: …
GI Georg, J Kant, HS Gill
Index: Georg, Gunda I.; Kant, Joydeep; Gill, Harpal S. Journal of the American Chemical Society, 1987 , vol. 109, # 4 p. 1129 - 1135
Abstract: The synthesis of (l'R, 3R, 4R)-4-acetoxy-3-(l'-((tert-butyldimethylsilyl) oxy) ethyl)-2- azetidinone, an important precursor for the synthesis of carbapenems and penems, is detailed. The methodology utilized relies on the addition, cyclization reaction between the dianion of (S)-(+)-ethyl 3-hydroxybutanoate and N-arylaldimines. The syntheses of other useful optically active 3-(hydroxyethyl)-2-azetidinones are presented. A study of factors ...