ZBIGNIEW CZARNOCKI, DAVID B. MACLEAN, and WALTER A. SZAREK. Can. J. Chem. 64, 2205 (1986). The utility of the Pictet-Spengler condensation of (R)-(+)-glyceraldehyde with dopamine hydrochloride in the enantio- selective synthesis of isoquinoline alkaloids is demonstrated by