Two optically active (100% enantiomeric excess) isomers (13a and 13b) of ofloxacin (1)[(±)- ofloxacin; DL-8280;(±)-9-fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H- pyrido [1, 2, 3-de][1, 4] benzoxazine-6-carboxylic acid] and their fluoromethyl derivatives (14a and 14b) were prepared via their optically active intermediates resolved by use of high- performance liquid chromatography (HPLC). The isomers (13a and 13b) were also ...
![(S)-ethyl 3-(((3,5-dinitrobenzoyl)oxy)methyl)-9,10-difluoro-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate Structure](https://image.chemsrc.com/caspic/179/106939-31-5.png)
![(-)-ethyl 9,10-difluoro-2,3-dihydro-3-iodomethyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate Structure](https://image.chemsrc.com/caspic/016/113472-54-1.png)