e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Heterocyclic syntheses on the basis of arylation products of unsaturated compounds: X. 3-Aryl-2-chloropropanals as reagents for the synthesis of 2-amino-1, 3- …
…, VS Matiichuk, RY Vasylyshin, YV Ostapyuk
Index: Obushak; Matiichuk; Vasylyshin; Ostapyuk Russian Journal of Organic Chemistry, 2004 , vol. 40, # 3 p. 383 - 389
Abstract Meerwein reaction of arenediazonium chlorides with acrolein gave 3-aryl-2- chloropropanals which were brought into cyclocondensation with thiourea. The resulting 2- amino-5-benzyl-1, 3-thiazoles were acylated with carboxylic acid chlorides and phthalic anhydride to afford, respectively, 2-acylamino-5-benzyl-1, 3-thiazoles and N-(5-benzyl-1, 3- thiazol-2-yl) phthalimides.
