The preceding paper'within this series discussed the structureactivity relationship in a series of 6-substituted l-phenyl-3-(4-piperidinyl)-1H-indoles, which led to the selective and highly potent serotonin 5-HT2 antagonist Lu 26-042 (1, Figure 1). These compounds were the result of further development of a series of 5-substituted l-phenyl-3-(4-piperidinyl)-1H- indoles, which in addition to binding affinity for serotonin 5HT2 receptors, have strong ...
