A series of 3-phenyl-2-piperazinyl-5H-l-benzazepines and related compounds were synthesized and evaluated for potential neuroleptic activity. The preparation of these compounds was carried out by 2, 3-dichlorination of 3-phenyl-2, 3, 4, 5-tetrahydro-lH-l- benzazepin-2-ones with phosphorus pentachloride followed by amination and concurrent dehydrochlorination. Compounds having the 4-chloro or 4-fluor0 substituent in the 3- ...
