The synthesis of methyl 5-O-benzoyl-2-chloro-2, 3-dideoxy-3-fluoro-β-d-ribofuranoside (5) and its use as a glycosylating agent for persilylated thymine, N 6-benzoyladenine, and N 4- benzoylcytosine are described (Scheme 1). The 2'-chloro-2', 3'-dideoxy-3'-fluoro-d- ribonucleosides 10-12 synthesized were transformed to 2', 3'-dideoxy-3'-fluoro-α-and-β-d- erythro-pentofuranoside nucleosides of thymine (13a, b), adenine (14a, b), and cytidine ( ...
