Synthesis of 5??deazaflavin adenine dinucleotide (5??dFAD) using a modified triester approach

…, JAJ Den Hartog, GA Van der Marel…

Index: Smit, P.; Stork, G. A.; van der Plas, H. C.; den Hartog, J. A. J.; van der Marel, G. A.; van Boom, J. H. Recueil des Travaux Chimiques des Pays-Bas, 1986 ,  vol. 105, p. 538 - 543

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Citation Number: 13

Abstract

Abstract Starting from D-ribose and 3, 4-xylidine, a fifteen-step synthesis is described for the preparation of 5-dFAD (18). The synthesis involves as key intermediates, 5-deazariboflavin (8), its 2′, 3′, 4′-tris-O-(tetrahydropyranyl) derivative (12) and 2′, 3′, 4′-tris-O- (tetrahydropyranyl)-5′-O-(morpholinophosphonyl)-5-deazariboflavin (15).