Tri-and tetrapeptide analogs of kinins as potential renal vasodilators

…, PA Chambers, EE Hilbert, PW Woodward…

Index: Pfeiffer; Chambers; Hilbert; Woodward; Ackerman Journal of Medicinal Chemistry, 1984 ,  vol. 27,  # 3  p. 325 - 341

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Citation Number: 8

Abstract

Medicinal Chemistry and Pharmacology, Research and Development Division, Smith Kline & French Laboratories, Philadelphia, Pennsylvania 19101. Received July 15, 1983'hi-and tetrapeptide analogues were synthesized and evaluated as renal vasodilators. These peptides were prepared by standard coupling reactions, which also provided good yields with hindered a-methyl amino acid derivatives. Preliminary evidence of renal vasodilator ...