A Convenient Synthesis of α, β-Acetylenic Ketones

P Li, WM Fong, LCF Chao, SHC Fung…

Index: Li; Wai Man Fong; Chao; Fung; Williams Journal of Organic Chemistry, 2001 , vol. 66, # 11 p. 4087 - 4090

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Citation Number: 27

Abstract

R, β-Acetylenic ketones are extremely versatile intermediates for the preparation of various heterocyclic compounds, 1 anticancer agents, 2 pyroazole derivatives, 3 nucleosides, 4 sex pheromones5 and β-keto-1, 3-dithianes6 as well as other compounds. 7 Thus, considerable effort has been devoted to the preparation of conjugated acetylenic ketones based on a wide variety of synthetic approaches including the acylation of metal acetylides, 8 Cu (I)- ...

 Related Synthetic Route
4-Nonyne Structure

20184-91-2

4-Nonyne

~39%

non-4-yn-3-one Structure

1817-61-4

non-4-yn-3-one

5-nonyn-4-one Structure

73368-69-1

5-nonyn-4-one

Hex-3-yne Structure

928-49-4

Hex-3-yne

~57%

3-Hexyn-2-one Structure

1679-36-3

3-Hexyn-2-one

4-Octyne Structure

1942-45-6

4-Octyne

~0%

oct-4-yn-3-ol Structure

10307-00-3

oct-4-yn-3-ol

oct-4-yn-3-one Structure

7299-56-1

oct-4-yn-3-one

3-heptyne Structure

2586-89-2

3-heptyne

~35%

3-HEPTYN-2-ONE Structure

26059-43-8

3-HEPTYN-2-ONE

4-Heptyn-3-one Structure

32398-68-8

4-Heptyn-3-one

1-Pentyn-1-ylbenzene Structure

4250-81-1

1-Pentyn-1-ylbenzene

~%

1-phenyl-1-pentyn-3-ol Structure

27975-78-6

1-phenyl-1-pent...

3-heptyne Structure

2586-89-2

3-heptyne

~31%

3-HEPTYN-2-ONE Structure

26059-43-8

3-HEPTYN-2-ONE

4-Heptyn-3-one Structure

32398-68-8

4-Heptyn-3-one

2-Decyne Structure

2384-70-5

2-Decyne

~70%

dec-2-yn-4-one Structure

34695-28-8

dec-2-yn-4-one

Oct-1-yne Structure

629-05-0

Oct-1-yne

~50%

oct-1-yn-3-one Structure

27593-19-7

oct-1-yn-3-one


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