A Convenient Synthesis of α, β-Acetylenic Ketones

P Li, WM Fong, LCF Chao, SHC Fung…

Index: Li; Wai Man Fong; Chao; Fung; Williams Journal of Organic Chemistry, 2001 , vol. 66, # 11 p. 4087 - 4090

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Citation Number: 27

Abstract

R, β-Acetylenic ketones are extremely versatile intermediates for the preparation of various heterocyclic compounds, 1 anticancer agents, 2 pyroazole derivatives, 3 nucleosides, 4 sex pheromones5 and β-keto-1, 3-dithianes6 as well as other compounds. 7 Thus, considerable effort has been devoted to the preparation of conjugated acetylenic ketones based on a wide variety of synthetic approaches including the acylation of metal acetylides, 8 Cu (I)- ...