Trifluoromethyl-promoted homocamptothecins: Synthesis and biological activity

…, W Guo, J Yao, W Liu, X Che, W Wang, P Cheng…

Index: Zhu, Lingjian; Miao, Zhenyuan; Sheng, Chunquan; Guo, Wei; Yao, Jianzhong; Liu, Wenfeng; Che, Xiaoying; Wang, Wenya; Cheng, Pengfei; Zhang, Wannian European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2726 - 2732

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Citation Number: 22

Abstract

The homocamptothecin (hCPT) represents a new class of topoisomerase inhibitor which combines enhanced plasma stability and strong antitumor activity. Fluorine imparts desirable characteristics to drugs by modulating both the pharmacokinetics and pharmacodynamic properties of a drug. Therefore, in an attempt to improve the antitumor activity of homocamptothecins, seven new 7-trifluoromethylated homocamptothecin ...

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