Tetrahedron Letters

A new asymmetric 1, 4-addition method: application to the synthesis of the HIV non-nucleoside reverse transcriptase inhibitor DPC 961

NA Magnus, PN Confalone, L Storace

Index: Magnus, Nicholas A.; Confalone, Pat N.; Storace, Louis Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3015 - 3019

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Citation Number: 46

Abstract

The asymmetric synthesis of the HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) DPC 961 is achieved in three steps with an overall yield of> 55%. The asymmetry is induced by the chiral auxiliary (R)-(+)-α-methylbenzylamine, utilizing a new asymmetric 1, 4-addition protocol.