Combination of a dinuclear Zn2+ complex and a medium effect exerts a 1012-fold rate enhancement of cleavage of an RNA and DNA model system

…, CI Maxwell, MF Mohamed, CJ White…

Index: Neverov, Alexei A.; Lu, Zhong-Lin; Maxwell, Christopher I.; Mohamed, Mark F.; White, Christopher J.; Tsang, Josephine S. W.; Brown, R. Stan Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 16398 - 16405

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Citation Number: 71

Abstract

The catalytic ability of a dinuclear Zn2+ complex of 1, 3-bis-N 1-(1, 5, 9-triazacyclododecyl) propane (3) in promoting the cleavage of an RNA model, 2-hydroxypropyl-p-nitrophenyl phosphate (HPNPP, 1), and a DNA model, methyl p-nitrophenyl phosphate (MNPP, 4), was studied in methanol solution in the presence of added CH3O-at 25° C. The di-Zn2+ complex (Zn2: 3), in the presence of 1 equiv of added methoxide, exhibits a second-order rate ...