Palladium??Catalyzed Selective C H Benzylation towards Functionalized Azoles with a Quaternary Carbon Center

P Xie, H Huang, Y Xie, S Guo…

Index: Xie, Pan; Huang, Hanmin; Xie, Yinjun; Guo, Shengmei; Xia, Chungu Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1692 - 1700

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Citation Number: 5

Abstract

Abstract The direct C [BOND] H benzylation of azoles with benzyl chlorides proceeds efficiently, via sequential cleavage of one sp 2 C [BOND] H bond and two sp 3 C [BOND] H bonds in the presence of a palladium catalyst, to generate a wide range of tribenzylated azoles with a quaternary carbon center efficiently. The same catalyst could also promote the mono-and di-benzylation reactions through fine turning of the base and reaction ...