Tetrahedron

A general enantioselective route to the chamigrene natural product family

…, IC Stewart, BA Seashore-Ludlow, RH Grubbs…

Index: White, David E.; Stewart, Ian C.; Seashore-Ludlow, Brinton A.; Grubbs, Robert H.; Stoltz, Brian M. Tetrahedron, 2010 , vol. 66, # 26 p. 4668 - 4686

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Citation Number: 35

Abstract

Described in this report is an enantioselective route toward the chamigrene natural product family. The key disconnections in our synthetic approach include sequential enantioselective decarboxylative allylation and ring-closing olefin metathesis to form the all- carbon quaternary stereocenter and spirocyclic core present in all members of this class of compounds. The generality of this strategy is demonstrated by the first total syntheses of ...