An easy access to asymmetrically substituted oligoethylene glycols from 18-crown-6

PI Abronina, AI Zinin, AV Orlova, SL Sedinkin…

Index: Abronina, Polina I.; Zinin, Alexander I.; Orlova, Anna V.; Sedinkin, Sergey L.; Kononov, Leonid O. Tetrahedron Letters, 2013 , vol. 54, # 34 p. 4533 - 4535

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Abstract

However, penta- and hexaethylene glycols (n = 5, 6) are much more expensive in contrast to shorter analogs. 11 For this reason, we propose an alternative route for the preparation of multigram quantities of the heterobifunctional OEG derivatives (n = 6, 7) based on decyclization of crown-ethers, which are several times cheaper than the corresponding OEGs of similar chain length. ... After considerable experimentation we developed a preparative version of this ...