Versatile solid-phase thiolytic reduction of azido and N-Dts groups in the synthesis of haemoglobin (67–76) O-glycopeptides and photoaffinity labelled analogues to …

…, O Werdelin, L Galli-Stampino, S Mouritsen…

Index: Meinjohanns, Ernst; Meldal, Morten; Jensen, Teis; Werdelin, Ole; Galli-Stampino, Luisa; Mouritsen, Soren; Bock, Klaus Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 871 - 884

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Citation Number: 38

Abstract

A series of O-glycosylated peptides and photoaffinity labelled glycopeptide analogues of the mouse haemoglobin-derived decapeptide Hb (67–76), VITAFNEGLK, which binds well to the MHC class II Ek molecule and is non-immunogenic in CBA/J mice, was synthesized by multiple-column peptide synthesis employing the glycosylated building blocks 1–4 and 7– 21. The non-immunogenic peptide VITAFNEGLK was converted into an immunogen by ...