Synthetic Communications

Propanephosphonic Acid Anhydride–Mediated Cyclodehydration of Maleic Acid Monoamides

I Klimenkovs, E Bakis, A Priksane

Index: Klimenkovs, Igors; Bakis, Eduards; Priksane, Anda Synthetic Communications, 2013 , vol. 43, # 19 p. 2634 - 2640

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Abstract

Propanephosphonic acid anhydride (T3P) has been proposed as a novel reagent for the preparation of maleic acid isoimides from the corresponding monoamides. A series of substituted aromatic and aliphatic isoimides have been prepared in good yields. The main advantage of this synthetic method is the use of environmentally benign, cost-efficient reagents and solvents, which are also safer to handle than the ones employed previously. ... Supplemental materials are ...