A study of chemical carcinogenesis. 84. Synthesis and fluorescence spectra of structural analogs of potential benzo [b] fluoranthene-DNA adducts

S Amin, G Balanikas, K Huie, N Hussain…

Index: Amin, Shantu; Balanikas, George; Huie, Keith; Hussain, Nalband; Geddie, J. Edgar; Hecht, Stephen S. Journal of Organic Chemistry, 1985 , vol. 50, # 23 p. 4642 - 4646

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Citation Number: 17

Abstract

A number of fluorine-substituted uracil derivatives show interesting biological activity. For example, 5-fluorouracil derivatives are useful as antitumor agents, and 5-(trifluoromethy1) deoxyuridine shows marked antiviral activity. l,* The binding of 6-substituted uracil to thymidine phosphorylase has been studied. The 6-trifluoromethyl derivative has been reported to bind to this enzyme sevenfold better than the 6-methyl analogue. Presumably ...