Synthesis of 5-(((R, S)-5-((9-Fluorenylmethoxycarbonyl) amino)-10, 11-dihydrodibenzo [a, d] cyclohepten-2-yl) oxy) valeric Acid (CHA) and 5-(((R, S)-5-((9- …

M Noda, M Yamaguchi, E Ando, K Takeda…

Index: Noda, Masaki; Yamaguchi, Minoru; Ando, Eiji; Takeda, Kenji; Nokihara, Kiyoshi Journal of Organic Chemistry, 1994 , vol. 59, # 26 p. 7968 - 7975

Full Text: HTML

Citation Number: 30

Abstract

Two novel handles for peptide amide preparation under mild conditions were developed for use in highly efficient solid-phase peptide synthesis. These handles, 5-{[(R, S)-5-[(9- fluorenylmethoxy-carbony1) aminol-l0, l l-dihydrodibenzo [u, dlcyclohepten-2-ylloxy} valeric acid (CHA) and 5-{[(R, S)-5-[(9-fluorenylmethoxycarbonyl) aminoldibenzo [u, dlcyclohepten- 2-ylloxy} vale~ c acid (CHE), were attached to the solid support and were used for ...