Tetrahedron letters

The first total synthesis of (±)-lagopodin A

A Srikrishna, BV Lakshmi, PC Ravikumar

Index: Srikrishna; Vasantha Lakshmi; Ravikumar Tetrahedron Letters, 2006 , vol. 47, # 8 p. 1277 - 1281

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Citation Number: 21

Abstract

The first total synthesis of (±)-lagopodin A and a formal total synthesis of enokipodins A and B is described. The requisite precursors containing two vicinal quaternary carbon atoms were assembled employing Claisen rearrangement and an RCM reaction as key steps starting from 2, 5-dimethoxy-4-methylacetophenone.