Synthesis, characterization and anticonvulsant activity of enaminones. Part 6: Synthesis of substituted vinylic benzamides as potential anticonvulsants

JE Foster, JM Nicholson, R Butcher, JP Stables…

Index: Foster, James E.; Nicholson, Jesse M.; Butcher, Raymond; Stables, James P.; Edafiogho, Ivan O.; Goodwin, Angela M.; Henson, Michael C.; Smith, Carlynn A.; Scott Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2415 - 2425

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Citation Number: 93

Abstract

A comparison of enaminones from various unsubstituted and p-substituted benzamides to the analogous benzylamines has been undertaken with the aim of elucidating the essential structural parameters necessary for anticonvulsant activity. Initial studies on methyl 4-N- (benzylamino)-6-methyl-2-oxocyclohex-3-en-1-oate, 3a, 3-N-(benzylamino) cyclohex-2-en-1- one, 3p, and 5, 5-dimethyl-3-N-(benzylamino)-cyclohex-2-en-1-one, 3r indicated that ...