Tetrahedron

2, 2-Dichlorination of Aldehydes with the 2, 6-Lutidine· HCl/Cl 2/CH 2 Cl 2 System: an Environmentally Benign Process Suitable for Scale Up

…, F Ghelfi, E Libertini, UM Pagnoni, F Roncaglia

Index: Bellesia, Franco; De Buyck, Laurent; Ghelfi, Franco; Libertini, Emanuela; Pagnoni, Ugo Maria; Roncaglia, Fabrizio Tetrahedron, 2000 , vol. 56, # 38 p. 7507 - 7511

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Citation Number: 13

Abstract

An effective and environmentally benign preparation of 2, 2-dichloroaldehydes has been achieved by chlorination of aldehydes with Cl2 (g) in CH2Cl2, using 2, 6-lutidine hydrochloride as recoverable catalyst. Remarkable qualities of the process are: easy work up, high purity products, HCl as the only 'waste'stream and inherent bias to the scale up.