Chemical synthesis of O-ethyl-L-homoserine, a new amino acid produced by Corynebacterium ethanolaminophilum

Y Murooka, T Harada, Y Izumi

Index: Murooka; Harada; Izumi Bulletin of the Chemical Society of Japan, 1968 , vol. 41, # 3 p. 633 - 635

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Citation Number: 10

Abstract

The synthesis of O-ethyl-DL-homoserine (V) was achieved by the condensation of β- ethoxyethylbromide (II) with diethyl acetoaminomalonate (III) and by the successive hydrolysis of diethyl ethoxyethylacetoaminomalonate (IV) with hydrochloric acid. The optical resolution of O-ethylhomoserine was performed enzymatically using papain. The O-ethyl-L- homoserine (VIII) obtained by the resolution was shown to be identical with the amino acid ...