Pyrroles are not only important building blocks in nature such as in hemes, chlorophyll, and various porphyrinoids, 1 but also commonly found as various kinds of derivatives in living cells to show biological activity. 2 Thus, there have been many synthetic studies on pyrrole derivatives. In 1993, Kato et al. isolated a novel lipid peroxidation inhibitor, pyrrolostatin (1a), from Streptomyces chrestomyceticus, which consists of a pyrrole-2-carboxylic acid with a ...
