The synthesis and antiviral activity of 4-fluoro-1-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide

R Storer, CJ Ashton, AD Baxter, MM Hann…

Index: Storer, Richard; Ashton, Claire J.; Baxter, Anthony D.; Hann, Michael M.; Marr, Clara L. P.; Mason, Andrew M.; Mo, Chi-Leung; Myers, Peter L.; Noble, Stewart A.; Penn, Charles R.; Weir, Niall G.; Woods, Jacqueline M.; Coe, Paul L. Nucleosides and Nucleotides, 1999 , vol. 18, # 2 p. 203 - 216

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Citation Number: 59

Abstract

Abstract A novel fluoropyrazole ribonucleoside has been shown to have significant anti- influenza activity in vitro. The compound is compared and contrasted with the structurally- related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds.