Chiral propargylic alcohols constitute important building blocks for asymmetric synthesis. They are used in diverse areas including the synthesis of natural products, pharmaceuticals, and macromolecules. 1., 2. and 3. The preparation of propargylic alcohols via the addition of alkynes to aldehydes is of great interest because both the CC bond and the stereogenic center can be formed in one step. Until now, nucleophilic alkynylation has enjoyed only very limited ...
