Total synthesis of carolacton, a highly potent biofilm inhibitor

T Schmidt, A Kirschning

Index: Schmidt, Thomas; Kirschning, Andreas Angewandte Chemie - International Edition, 2012 , vol. 51, # 4 p. 1063 - 1066

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Citation Number: 28

Abstract

Recently, we discovered and isolated carolacton (1) from the extracts of Sorangium cellulosum strain So ce96.[1] Subsequent screening revealed unique biological properties of carolacton (1): it drastically reduces the number of viable cells in biofilms at nanomolar concentration.[2] In particular, biofilms containing the caries-and endocarditis-associated bacterium Streptococcus mutans were sensitive to a solution of 1 at a concentration of ...